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Introduction: Why Should You Read This Book ?

In theory, there is no difference between theory and practice.
In practice there is.

—YOGI BERRA

In "The Structure of Scientific Revolutions", Thomas Kuhn! says that advances in science do not occur in an evolutionary or straight-line manner. Instead, such steps take place in a series of violent revolutions sepa￾rated by long periods of relative peace.
During dramatic uprisings, “one conceptual world view replaces another.”
These intellectual revolts are not random events.
They are promoted by the discovery of significant anomalies: emergent facts that the ruling dominant theory and its supporters fail to adequately explain.
These “exceptions to the rule” are the termites of scientific theory.
As they multiply, they become more and more difficult to ignore.
The newly infected ruling theory weakens until it eventually collapses.
A paradigm shift occurs as another takes its place.
While the drug-based pharmaceutical industry continues to control con￾ventional medicine, its support structure is increasingly termite riddled.
Weaknesses are being illustrated by new highly critical books, with titles such as Deadly Medicine*, Overdo$ed America, and Death by Modern Medicine*.
Of course, the drug-based approach to health will not be abandoned any time soon unless society has a viable alternative, waiting, like an understudy, in the wings.
There it must be quietly attracting its own, more open-minded supporters.
The authors of this book are members of one such group: advocates of orthomolecular (nutrition-based) medicine. They support an approach to human wellness that involves the use, not of drugs, but of substances that naturally occur in the human body.
Niacin is one of these, and as such seems destined to eventually play a significant role in the upcoming, inevitable medical paradigm shift.
It is impossible here to show all the advantages society will gain by switching to nutrition-based medicine.
However, this initial chapter provides a variety of examples drawn from several specific categories of wellness. The remainder of the book seeks to examine, in much more detail, the case that can be made for the far more
widespread use of one such nutrient, niacin, for the prevention and treatment of health issues.
By eating diets that are deficient in essential nutrients, many individu￾als trigger their own chronic degenerative diseases later in life. It has been known for millennia that the basis for health is good nutrition.
Orthomol￾ecular medicine, a description coined in 1968 by Linus Pauling,® goes further.
Pauling describes a medical modality that uses nutrients and normal (that is, “ortho”) constituents of the body in specific optimum quantities as the dominant treatment.
Such health-nutritional relationships have been comprehensively explored most recently by Hoffer and Saul in Orthomol￾ecular Medicine for Everyone: Megavitamin Therapeutics for Families and Physicians’.
It has been further recognized that individuals are unique in their daily requirements for vitamins, minerals, or protein.8 For each nutrient, at least 2.5 percent will need higher levels than the rest of the population.
There are about three dozen nutrients.
Doing the math, it becomes apparent that most people are deficient in something—even if they consume USRDA (United States Recommended Dietary Allowance) nutrient levels every day.
We are all different, and you are a bit different every day.
Illness, medications, age, variations in diet, fatigue, and stress are among the many factors that today can make you different from the you of yesterday. It has been said that you are what you eat.

“Orthomolecular” means the right or the correct molecule.
The name was coined by Linus Pauling in 1968.
Conventional pharmaceuticals tend to be “toximolecular.”
Vitamins and insulin are examples of orthomolecular therapeutic substances.
Chemotherapy would be an example of a toximolecular therapy.

This very orthomolecular concept is true.
But, in a deeper way, you are what you absorb.
To illustrate, as Hof￾fer and Saul point out:

"In regard to nutrients, there may be a problem with absorption in the intestine.
Thus with pernicious anemia, specific areas in the gut that normally absorb vitamin B12, are lacking, or after the vitamin is absorbed it may not be combined effectively into its coenzyme, or it may be wasted or held too tenaciously by some organ system, thus depriving other parts of the body."

We need all the nutrients all the time, in the same way that an aircraft needs all its wheels and wings.
Roger Williams has described a basic concept called the “orchestra principal.”
Just as it is impossible to claim that one instrument in an orchestra is more important than another, so to maintain health, all the nutrients required by the body must be available to ensure well-being.
Though impossible to outline the enormous number of illnesses that can develop as a result of nutritional imbalance, we can illustrate the principle.
It seems likely that calcium and selenium deficiencies promote many cancers,!! excess aluminum and inadequate magnesium and calcium are linked to Alzheimer’s disease, and a lack of sulfur is associated with osteoarthritis. Certainly there are many other wellknown nutrition-illness connections as well.
As will be seen from the remainder of this book, niacin plays an espe￾cially significant role in orthomolecular medicine.
Inevitably, its use will increase as the medical paradigm shift occurs.
Orthomolecular treatments are typically far less expensive than drug-based conventional protocols.
Embracing orthomolecular treatments will make prevention and treatment available to the poor.
If this statement might seem overly ambitious, we might consider this: a single orange may cost one dollar.
It would provide about 50 milligrams (mg) of vitamin C.
A bottle of 100 tablets of vitamin C, 500 mg each, costs about five dollars.
In terms of vitamin content, the orange gives you 50 mg per dollar.
The supplement gives you 10,000 mg per dollar.
There are of course other nutritional factors and advantages to eating oranges, such as sugars, taste, bioflavinoids, and fiber.
However, one cannot easily deny, at least in terms of vitamin C, that the supplement is 200 times cheaper, costing about half a cent for the amount of vitamin C in a one-dollar orange.
Even if your oranges could cost only one-tenth as much, an impossible ten cents each, the supplement is still twenty times cheaper.
The same is true for niacin.
Niacin supplements cost approximately five dollars for 100 tablets of 250 mg each.
That works out to be about 5,000 mg niacin per dollar.
Healthy foods naturally containing significant amounts of niacin cost far more.
Once again, the many nutritional advantages of eating kidneys, liver, whole-grain bread, nuts, and green leafy vegetables are considerable and undeniable. In terms of niacin con￾tent, however, there is no competition. Several dollars’ worth of these foods provides only tens of milligrams of niacin.
Niacin-fortified foods such as breakfast cereals, white bread, and pasta are slightly cheaper niacin sources, but not much.
Interestingly, the fact that milled grains have any niacin at all is due to niacin being added to them in the man￾ufacturing process.
Adding niacin to foods is a form of low-dose sup￾plementation.
The USRDA, which is far too low, is less than 18 mg.
Yet bodily need for niacin varies with activity, body size, and illness.
!+ About half of all Americans will not get even the RDA amount of niacin from their diets.
Niacin’s special importance is indicated in that the US RDA for niacin, which again we say is a very low figure, is actually twenty or more times higher than the RDA for other B vitamins.
Twenty teaspoons will not clean up after a hurricane much faster than one will.
We think that a lack of sufficient niacin is a real and continuing public health problem.

Preface

Many people have no idea how many illnesses are caused by too little niacin, and practically no one realizes just how many illnesses can be cured with megadoses of niacin.
It is the authors’ intent to change that.
Our objective is to provide a reader-friendly, problem-solving book.
This book is not nearly so much about the niacin molecule as it is about what can be done with a lot of niacin molecules.
Therefore, this book concentrates on niacin’s clinical benefits in a number of health conditions.
These conditions, successfully treated by pioneering niacin researcher Abram Hoffer, M.D., Ph.D., are based on his more than fifty years of medical practice.
Dr. Hoffer, whose capacity for work continually astounded me, began this book at the age of ninety-one. Unfortunately, he died before it was completed.
Medical geographer and professor Harry Foster, our coauthor and long-time collaborator, also suffered untimely death dur￾ing the early stages of writing this work.
So, if you wonder why this book is not thicker and more comprehensive, there you have your main reasons.
This is most certainly not a textbook.
However, standing on the shoulders of these two giants of nutritional science, I have endeavored to add to and complete the existing manuscript without altering Abram’s and Harry’s voices: Harry, the medical theorist and scholar, and Abram, the experienced and courageous physician and researcher.
(You often will find Dr. Hoffer’s voice in this book, in first person, with the initials AH following in parentheses.) The other voice is mine (AWS), that of the teacher, raconteur, and parent.
I am honored beyond measure to have worked for years with Dr. Hoffer and Dr. Foster.
I think Abram Hoffer and Harry Foster were, and will ever be, regarded as two of the great medical innovators of the modern era.
Dr. Hoffer was the world authority on niacin.
This constitutes his final work, of which he said, simply: “This book is designed primarily for cli￾nicians and the public who want to learn more and more about niacin and its wonderful properties.”
I hope this handbook may prove to be a significant part of his legacy, and of real help to all readers.

—Andrew W. Saul
November 2011

Foreword of the book Niacin raises good cholesterol (HDL) more than any known pharmaceutical, while simultaneously lowering total cholesterol, triglycerides, and the most pathogenic form of cholesterol-associated lipoprotein (VLDL). This wide array of generally clinically desirable chemical adjustme...

Plus no-flush niacin seems to work differently in the human body when compared to standard flushing niacin accoding to the doctor.
And that flush goes away in one or two weeks, provided you keep taking the niacin.
When you stop and start again the flush will also be back for a short while.

That niacin rush or flush is just the capillaries in your skin having a thorough "bleed through", and according to the book this is actually a good thing, although the feeling itself isn't very pleasant (your skin can even get itchy for a while) The doctor also says that healthy people seem to exper...

Just finished reading this book, and already have niacin (in powdered form) on order. Due to growing medication shortages the search for alternatives is growing, and besides many other health benefits niacin can completely replace statins, and this while being both safe & cheap. At least some of you...

Please continue the series, love it

I will go so far as to say that most supplements have no noticeable effect on me. However i've found a few exceptions over the years. In no particular order: Vitamin C in high dosages (5 to 10 grams a day) it's effect: just feeling better all round. Got the idea from the late professor Linus Pauling...

For arthritis and several other ailments you could look into bromelain, a natural compound extracted from pineapples. It has a multitude of uses, is extremely safe, and you don't need a prescription. Arthritis: https://pubmed.ncbi.nlm.nih.gov/?term=bromelain+arthritis Pain: https://pubmed.ncbi.nlm.n...

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What you do is probably the best form of earthing, but in my part of the world (and in my specific case) that is not always an option. For me the jury is still out on the inflammation part, hopefully i notice something in the long run. Do you by any chance have arthritis (bone & ligaments) or osteo-...

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